Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Human Topo I dependent cytotoxicity of CPTs and luotonin A towards Saccharomyces cerevisiae.a)
| Compound | Concentration (μM) | Inhibition on growth medium (%) | Topo I dependent cytotoxicity (IC50, μM)b) | |
|---|---|---|---|---|
| Raffinose | Galactose | |||
| CPT | 1.0 | 0 | 74 | 0.15 |
| Luotonin A (1aa) | 1.0 | 0 | 36 | |
| 0.5 | 0 | 23 | ||
| 14-aza-CPT (53a) | 2.0 | 0 | 46 | >10 |
| 53b | 1.28 | |||
a) Inhibition of RS321Nph-Topo I grown in minimal medium containing 3% raffinose or galactose for 2 days at 30 °C. b) Values were obtained against A549 cells using an MTT assay.
