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Comparison of LOPHTOR vs. batch reaction modes.
| Transformation | LOPHTOR | Batch | ||
|---|---|---|---|---|
| Time [h] | Yield [%] | Time [h] | Yield [%] | |
| 10 → 11 | 4 | 99 | 48 | 67 |
| 12 → 13 | 7 | 50 (1:1 a) | 24 | 30 (1:1 a) |
| 14 → 15 + 16 | 5 | 40 (7:1 b) | 24 | 25 (8:1 b) |
a Diastereoselectivity; b Regioselectivity (15 vs. 16).
