Table 1.
Cytochrome/Substrate | This study | Reference | ||||
---|---|---|---|---|---|---|
Km (µM) | IC50 (µM) | Km (µM) a | IC50 (µM) a,b | |||
3A4/BFC | 48.94 | 0.045 | 50 | 0.06 ± 0.016 b 0.09 ± 0.03 a |
||
2D6/AMMC | 1.016 | 0.005 | 1.5 | 0.0069 ± 0.0006 b 0.5 ± 0.2 a |
||
1A2/CEC | 23.69 | 0.755 | 25 | 0.58 ± 0.05 b 1.4 ± 0.3 a |
||
2C19/CEC | 4.627 | 2.511 | 5 | 2 ± 0.5 b 3.2 ± 1.2 a |
a Reference from database of Aurigene Discovery Technologies, Ltd.; b Donato et al. [13]. Data were expressed in standard error of the mean (S.E.M).