Fig 3. Mosquito MKPs are homologous to fruit fly, human, and mouse MKPs.

(A) A. gambiae (Ag) and A. stephensi (As) MKPs possess the highly conserved extended active site sequences and residues required for MKP catalysis, DX₂₆VLVHCX(A/M)G(V/I)SRSX₅AYLM, suggesting that the encoded proteins are enzymatically active. (B) Phylogenetic tree based on MKP catalytic domain sequences. Highly homologous mosquito MKP proteins are grouped with class II, class III, and atypical DUSPs. Class I MKPs are not encoded in the A. gambiae, A. stephensi, D. melanogaster or C. elegans genomes. Circles and squares denote A. gambiae and A. stephensi MKP proteins, respectively.