Table 3. Moderate inhibition of JNK reduces P. falciparum oocyst development in A. stephensi.
Control | JNK-IN-8 | TCS JNK 6o | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Exp | N | mean oocyst±SEM | % inf | N | mean oocyst±SEM | % inf | p-value | N | mean oocyst±SEM | % inf | p-value |
1 | 42 | 0.71±0.13 | 52.4 | 38 | 0.34±0.12 | 21.1 | 0.0097 | 38 | 0.39±0.12 | 36.3 | 0.0366 |
2 | 38 | 1.11±0.20 | 57.9 | 42 | 0.43±0.10 | 35.7 | 0.0114 | 41 | 0.56±0.13 | 39.0 | 0.0574 |
3 | 46 | 1.20±0.18 | 67.4 | 41 | 0.54±0.14 | 31.7 | 0.0032 | 44 | 0.73±0.15 | 45.5 | 0.0666 |