Table 2.
Renal function test of rats used in acute toxicity assessments of 1-(2-ketoiminoethyl)piperazine Schiff bases.
| Animals | Sodium (mmol/L) | Potassium (mmol/L) | Chloride (mmol/L) | Carbon dioxide (mmol/L) | Anion gap (mmol/L) | Urea (mmol/L) | Creatinine (µmol/L) |
|---|---|---|---|---|---|---|---|
| Control | 132.9 ± 2.1 | 6.14 ± 2.5 | 111.30 ± 3.5 | 16.12 ± 2.6 | 32.80 ± 2.9 | 7.40 ± 2.5 | 29.45 ± 9.6 |
| 2HP (2 g/kg) | 132.2 ± 3.5 | 6.27 ± 4.1 | 108.24 ± 4.2 | 19.18 ± 0.8 | 29.60 ± 1.2 | 7.10 ± 4.2 | 27.60 ± 6.4 |
| 2HP (5 g/kg) | 133.1 ± 4.1 | 6.35 ± 3.2 | 106.31 ± 3.8 | 17.51 ± 2.7 | 29.50 ± 3.6 | 7.30 ± 3.7 | 25.91 ± 8.3 |
| DHP (2 g/kg) | 133.5 ± 0.9 | 6.29 ± 0.4 | 109.71 ± 6.2 | 18.31 ± 0.4 | 28.70 ± 4.2 | 6.90 ± 2.1 | 26.22 ± 2.1 |
| DHP (5 g/kg) | 134.1 ± 1.8 | 6.37 ± 0.7 | 108.19 ± 2.4 | 19.72 ± 0.8 | 30.40 ± 3.2 | 7.10 ± 1.4 | 28.47 ± 1.6 |
| LP (2 g/kg) | 131.3 ± 2.2 | 6.52 ± 0.9 | 110.32 ± 2.1 | 18.34 ± 1.3 | 31.20 ± 2.5 | 7.01 ± 0.9 | 27.90 ± 1.3 |
| LP (5 g/kg) | 133.1 ± 0.4 | 6.44 ± 1.2 | 107.82 ± 3.2 | 14.26 ± 1.5 | 33.10 ± 3.4 | 6.8 0± 2.1 | 30.13 ± 0.4 |
Values expressed as mean ± S.E.M. There are no significant differences between groups. Significant value at p < 0.05.