Table 1.
In vitro antibacterial actitivity (MIC) of the tested diterpenes against periodontal bacteria.
| Microorganism (ATCC) | Minimum inhibitory concentration in µg mL−1 [µM] | ||||||
|---|---|---|---|---|---|---|---|
| # CHD | 1 | 2 | CA | 4 | 5 | 6 | |
|
B. fragilis (25285) |
7.4 [12.8] |
* | 25.0 [86.1] |
25.0 [82.1] |
100.0 [275.9] |
400.0 [1248.3] |
400.0 [1196.0] |
|
A. naeslundii (19039) |
1.8 [3.1] |
12.5 [40.8] |
25.0 [86.1] |
6.2 [20.4] |
25.0 [69.0] |
100.0 [312.0] |
50.0 [149.5] |
|
P. gingivalis (33277) |
0.9 [1.6] |
6.2 [20.2] |
6.2 [21.3] |
3.1 [10.2] |
25.0 [69.0] |
25.0 [78.0] |
50.0 [149.5] |
|
P. nigrescens (33563) |
0.9 [1.6] |
400.0 [1304.9] |
12.5 [43.0] |
200.0 [656.9] |
200.0 [551.7] |
200.0 [624.1] |
200.0 [598.0] |
|
F. nucleatum (25586) |
1.8 [3.1] |
400.0 [1304.9] |
50.0 [172.1] |
200.0 [656.9] |
200.0 [551.7] |
200.0 [624.1] |
200.0 [598.0] |
|
B. thetaiotaomicron (29741) |
29.0 [50.1] |
* | 50.0 [172.1] |
* | 400.0 [1103.4] |
400.0 [1248.2] |
* |
|
P. anaerobius (27337) |
7.4 [12.8] |
3.1 [10.1] |
12.5 [43.0] |
3.1 [10.2] |
12.5 [34.5] |
25.0 [78.0] |
25.0 [74.7] |
# Positive control; * Inactive in the evaluated concentrations.