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. 2018 Nov 29;37:294. doi: 10.1186/s13046-018-0957-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — miR-296-5p suppresses EMT and metastasis through NRG1. The miR-296-5p-KD Huh7 cells were transfected with siNRG1 and control siRNA, the miR-296-5p-OE MHCC97H cells were transfected with NRG1-expressing plasmids or the control plasmids for 48 h. The NRG1, secreted NRG1 proteins levels (a), EMT-associated morphological changes (b), EMT markers (E-cadherin and Vimentin) (c), the cellular metastasis (d) and motion ability (e) in the indicated cells. Magnification 200×. *p < 0.05, **p < 0.01, ***p < 0.001

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