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. 2018 Nov 28;37:292. doi: 10.1186/s13046-018-0970-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Inhibition of miR-6868-5p promotes CRC angiogenesis. a and b HUVECs were treated with the CM from HCT8 or HCT116 cells transfected with indicated miRNA inhibitors. Cell viability (a) and migration ability (b) of HUVECs were measured by CCK8 assay and wound healing assay respectively. Scale bar = 20 μm. c HUVECs were co-cultured with HCT8 or HCT116 cells transfected with indicated miRNA inhibitors in transwell apparatus. Migrated HUVECs were quantified after co-culture for 24 h. Scale bar = 20 μm. d HUVECs were treated with the CM from indicated cells, and subjected to tube formation assay. Scale bar = 20 μm.*p < 0.05, **p < 0.01