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. 2018 Nov 12;128(12):5634–5646. doi: 10.1172/JCI98595

Figure 1. Type 2 DM and prediabetes increase UPEC susceptibility.

Figure 1

(A) Representative Western blots probed for β-IR, pAKT (ser473), and GAPDH in db/+ and db/db mice. Each lane depicts kidney β-IR expression and AKT phosphorylation from separate mice. (B) Female db/+ and db/db mice were transurethrally inoculated with UPEC. At 24 hours after infection, urinary and bladder UPEC burdens were enumerated. Each point depicts bacterial burden in a separate mouse. The horizontal line indicates the geometric mean of each group. (C) Representative Western blots probed for β-IR, pAKT (ser473), and GAPDH from control and TALLYHO mice. Each lane depicts kidney β-IR expression and AKT phosphorylation from separate mice. (D) Urinary and bladder UPEC burdens in female control and TALLYHO mice 24 hours after infection. Asterisks denote significance for the indicated pairwise comparison (Mann-Whitney U test). *P < 0.05.