Figure 1. In silico models and biochemistry of carnosinol metabolism.

(A) Structure-activity relationships for l-carnosine and comparison with carnosinol. (B) Putative complex between carnosinol and CN1, highlighting the missing ion pair with Arg350 when compared with the corresponding complex for l-carnosine. (C) Putative complex between carnosinol and hPepT1, revealing that the inserted hydroxyl group elicits H-bonds similar to those already observed for l-carnosine.