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. 2018 Oct 22;128(12):5280–5293. doi: 10.1172/JCI94307

Figure 3. Carnosinol inhibits HNE-induced ubiquitin carbonylation.

Figure 3

(A) MS spectrum of ubiquitin control sample focusing on the z = 11 multicharged ion peak at m/z = 779; (B) 11+ peaks obtained upon incubation of ubiquitin with HNE, corresponding to unmodified (m/z = 779) and HNE-modified (m/z = 793) forms of the protein. (C and D) 11+ peaks obtained upon incubation of ubiquitin with HNE and carnosinol at 2 different molar ratios: HNE/carnosinol 1:0.5 mol/mol (C) and HNE/carnosinol 1:1 mol/mol (D), showing reduced intensity for the peak corresponding to the modified protein (m/z = 793).