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. 2018 Oct 22;128(12):5280–5293. doi: 10.1172/JCI94307

Figure 4. Dose-dependent mitigation of inflammation and metabolic disease parameters by carnosinol in HF diet–fed rats.

Figure 4

(A) Study design for HF diet–induced metabolic disease in a rat model. The effect of either a HF diet alone or in combination with low-dose (10 mg/kg) or high-dose (45 mg/kg) carnosinol or rosiglitazone in the drinking water on overall changes in body weight (B) and the levels of serum AGEs (C), TNF-α (D), IL-6 (E), C-reactive protein (F), triglycerides (G), cholesterol (H), glucose (I), and insulin (J). Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (K), along with liver triglycerides (L) and liver cholesterol (M) levels, are also shown. †P < 0.01 versus control diet; §P < 0.01 versus HF diet alone; *P < 0.01 versus HF plus carnosinol (10 mg/kg); 1-way ANOVA using a Newman-Keuls post hoc test for multiple comparisons (n = 6).