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. 2018 Oct 22;128(12):5280–5293. doi: 10.1172/JCI94307

Figure 5. Therapeutic effect of carnosinol on metabolic homeostasis and carbonyl stress in mouse models of diet-induced obesity.

Figure 5

The effect of a HFHS diet with and without carnosinol treatment is shown for glucose tolerance (A–C, n = 8) and insulin sensitivity of EDL (D) and soleus muscle (E) tissue upon termination of the study for each group (n = 6). Representative immunoblots for HNE adducts in whole-tissue homogenates prepared from mixed gastrocnemius skeletal muscle (F) and pancreas (H) tissue (n = 3 mice per group), along with the corresponding densitometric analysis (G and I). †P < 0.01 versus control diet within each respective genotype. A 2-way ANOVA followed by Tukey’s multiple comparisons test was used to test for the main effect of the treatment within each genotype.