Figure 5. Cardiac Ubqln1 deficiency exacerbates LV malfunction induced by acute myocardial IRI.

(A) Young adult homozygous Ubqln1-CKO mice and littermate control mice were subject to LAD ligation for 30 minutes, and then the ligation was released for reperfusion. At 23.5 hours after reperfusion, LV catheterization was performed to record LV pressure (B) and dP/dt (C, D) in vivo. ****P < 0.0001 vs. the respective sham group. Two-way ANOVA followed by Tukey’s test for pair-wise comparison. Each dot represents an individual animal.