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Secondary structures of various modified catalytic nucleic acids. Arrows indicate backbone cleavage sites. RNA, black; DNA, blue; LNA, purple. (a). ‘10–23’ DNAzyme, these modifications led to reduced activity [79]; (b). Hammerhead ribozyme, the shown modifications led to slightly improved multiple turnover kinetics [81]; (c). Leadzyme, this modification increased the activity 20-fold [86].
