Table 2.
ATH of acetophenone catalyzed by 1b in water [a].
| Entry | Catalyst config. | Solution | Time; Temp.; Conversion (%) | % ee (config) [b] | Ref. [c] |
|---|---|---|---|---|---|
| 1 | (R,R) | H2O/HCOONa | 2 h; 40 °C; >99 | 94 % (R) | [59] |
| 2 | (R,R) | HCOOH/Et3N | 12 h; 40°C; 98 | 97 % (R) | [59] |
| 3 | (R,R) | H2O/HCOONa/CTAB [d] | 4 h; 28 °C; >99 | 95 % (R) | [62] |
| 4 | (S,S) | H2O/HCOONa/PEG | 15 h; 40 °C; >99 | 96 % (S) | [63] |
[a] Molar ratio substrate/catalyst (S/C) = 100; The catalyst was formed in situ from the [RuCl2(η6-p-cymene)]2 dimer and TsDPEN; [b] See corresponding references for details on determination of ee and product configuration; [c] Reference containing data for a given entry. [d] CTAB = cetyltrimethyl-ammonium bromide.