Table 3.
The enhancing effects of MSKE and its phenolic principles on the antibacterial activities of penicillin G against S. aureus ATCC 25923 and 19 clinical MRSA isolates (a mean values ± S.D. of triplicate results, b mean values ± S.D.from 19 MRSA strains).
| Bacterial strains | MIC of Penicillin G (µg/mL)a | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Penicillin G alone | +MSKE 0.25MIC | +MSKE 0.5MIC | +PGG 0.25MIC | +PGG 0.5MIC | +MG 0.25MIC | +MG 0.5MIC | +GA 0.25MIC | +GA 0.5MIC | |
| S. aureus ATCC 25923 | 41.67 ± 18.04 | 3.91 ± 0.00 | 1.95 ± 0.00 | 7.81 ± 0.00 | 7.81 ± 0.00 | 31.25 ± 0.00 | 15.63 ± 0.00 | 15.63 ± 0.00 | 7.81 ± 0.00 |
| Clinical MRSA strains | |||||||||
| M 01 | 2,000.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 62.50 ± 0.00 | 1.95 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 02 | 2,000.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 125.00 ± 0.00 | 1.95 ± 0.00 | 250.00 ± 0.00 | 125.00 ± 0.00 |
| M 03 | 2,000.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 1,000.00 ± 0.00 | 500.00 ± 0.00 | 125.00 ± 0.00 | 1.95 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 04 | 1,333.33 ± 577.35 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 125.00 ± 0.00 | 1.95 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 05 | 2,000.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 125.00 ± 0.00 | 1.95 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 06 | 1,666.67 ± 577.35 | 250.00 ± 0.00 | 250.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 62.50 ± 0.00 | 1.95 ± 0.00 | 3.91 ± 0.00 | 3.91 ± 0.00 |
| M 07 | 2,000.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 125.00 ± 0.00 | 1.95 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 08 | 1,666.67 ± 577.35 | 250.00 ± 0.00 | 250.00 ± 0.00 | 1,000.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 125.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 09 | 1,666.67 ± 577.35 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 3.91 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 10 | 1,666.67 ± 577.35 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 125.00 ± 0.00 | 125.00 ± 0.00 | 3.91 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 11 | 2,000.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 3.91 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 12 | 4,000.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 1,000.00 ± 0.00 | 1,000.00 ± 0.00 | 2,000.00 ± 0.00 | 3.91 ± 0.00 | 1,000.00 ± 0.00 | 1,000.00 ± 0.00 |
| M 13 | 8,000.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 3.91 ± 0.00 | 125.00 ± 0.00 | 125.00 ± 0.00 |
| M 14 | 4,000.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 3.91 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 15 | 125.00 ± 0.00 | 62.50 ± 0.00 | 62.50 ± 0.00 | 7.80 ± 0.00 | 7.80 ± 0.00 | 3.91 ± 0.00 | 0.06 ± 0.00 | 3.91 ± 0.00 | 3.91 ± 0.00 |
| M 16 | 4,000.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 3.91 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 17 | 125.00 ± 0.00 | 62.50 ± 0.00 | 62.50 ± 0.00 | 31.25 ± 0.00 | 31.25 ± 0.00 | 3.91 ± 0.00 | 0.06 ± 0.00 | 3.91 ± 0.00 | 3.91 ± 0.00 |
| M 18 | 2,000.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 62.50 ± 0.00 | 3.91 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| M 19 | 2,000.00 ± 0.00 | 500.00 ± 0.00 | 500.00 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 | 62.50 ± 0.00 | 3.91 ± 0.00 | 250.00 ± 0.00 | 250.00 ± 0.00 |
| Mean MRSA (n = 19) b | 2,328.95 ± 1,729.87 | 361.84 ± 159.45 | 309.21 ±145.05 | 409.95 ± 300.04 | 324.42 ± 222.60 | 250.41 ± 439.73 | 9.16 ± 28.08 | 244.04 ± 205.36 | 237.46 ± 207.16 |