Table 1.
MICs/MBCs (μg/mL) of Tet, d-Tet and four antibiotics alone against ATCC 25923 and 10 clinical MRSA strains of SCCmec III type.
| Agents a | MIC/MBCs of ATCC 25923 (μg/mL) | MIC/MBCs of MRSA strains (μg/mL) | |||
|---|---|---|---|---|---|
| Range | 50% b | 90% | |||
| Tet | 64/128 | 64–128/256–1024 | 128/512 | 128/1024 | |
| d-Tet | 32/64 | 64–128/256–1024 | 64/512 | 128/1024 | |
| AMP | 32/64 | 32–128/256–512 | 64/512 | 128/512 | |
| AZM | >1,000/ nt | 2,000–4,000/ nt c | 4,000/ nt | 4,000/ nt | |
| CFZ | 64/128 | 128–256/ nt | 128/ nt | 256/ nt | |
| LEV | 4/8 | 8–32/32–64 | 16/64 | 16/64 | |
| VAN | 0.96/1.92 | 0.96/1.92 | 0.96/1.92 | 0.96/1.92 | |
a Tet: tetrandine; d-Tet: demethyltetrandrine; AMP: ampicillin; CFZ: cefazolin; LEV: levofloxacin; AZM: azithromycin; VAN: vancomycin; b 50% means MIC50, concentration of inhibition against 50% of MRSA strains; 90% means MIC90, concentration of inhibition against 90% of MRSA strains; c nt: Not determined.