Table 2. Significantly differentially expressed circulating plasma proteins in AF patients with- compared to patients without LVA.

UP–unique peptides of the protein identified in proteome screening, P–t-test p-value, P(FDR)–p-value with FDR, FC–fold change with LVA vs. without LVA, negative fold change indicates lower concentrations in the LVA group. An asterisk marks proteins that were also differentially abundant in patients with LAD<44mm vs. LAD≥44mm (significance in t-test but not following FDR).

Protein names	UP	P	P (FDR)	FC
Complement C1q subcomponent subunit B	4	0.005	0.044	-1.16
Complement C1q subcomponent subunit C	4	0.005	0.044	-1.16
Caspase-8	1	0.005	0.044	1.92
Complement factor H	40	0.000	0.018	-1.25
Properdin	3	0.005	0.044	-1.23
Cortactin-binding protein 2	1	0.003	0.039	1.76
Dynein heavy chain 12 axonemal	1	0.002	0.025	1.61
Coagulation factor IX	6	0.003	0.035	-1.35
Vitamin D-binding protein	24	0.001	0.018	-1.22
Hepatocyte growth factor activator	6	0.001	0.018	-1.27
Putative heat shock 70 kDa protein 7	1	0.001	0.018	1.77
Kin of IRRE-like protein 3	1	0.005	0.044	1.47
Phosphatidylcholine-sterol acyltransferase	5	0.001	0.018	-1.25
Mannosyl-oligosaccharide 12-alpha-mannosidase	1	0.001	0.018	1.54
Endonuclease 8-like 3	1	0.004	0.041	1.32
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	1	0.001	0.018	1.33
Protocadherin-15	1	0.006	0.046	-1.20
Peptidase inhibitor 16	1	0.001	0.020	-1.69
Plasminogen	22	0.001	0.018	-1.19
Ras-related GTP-binding protein B	1	0.003	0.039	1.44
L-selectin	2	0.000	0.018	-1.75
Kallistatin	8	0.001	0.018	-1.35
Thyroxine-binding globulin	11	0.001	0.018	-1.29
SWI/SNF complex subunit SMARCC1	1	0.001	0.018	2.49
Serine palmitoyltransferase 2	1	0.002	0.025	1.89
Transcription elongation factor SPT6	1	0.000	0.018	1.83
Protein-glutamine gamma-glutamyltransferase 6	1	0.005	0.044	1.41
E3 ubiquitin-protein ligase TRIM33	1	0.006	0.046	1.39
Tetratricopeptide repeat protein 39A	1	0.001	0.018	2.04
Zinc finger protein 30 homolog	1	0.001	0.018	1.75