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Hemodynamic factor (Ang-II) and metabolic factors (AGE and Glucose) are modulating expression of inflammatory markers like TGF-β1, NF-κB and IL-6 and oxidative stress markers like ROS. Because of increased expression of TGF-β1 there is downregulation of miR29b which leads to dysregulation of methylation and as a result causes hypermethylation of genome.
