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. Author manuscript; available in PMC: 2018 Nov 29.
Published in final edited form as: Int J Cancer. 2014 Jun 17;137(6):1249–1257. doi: 10.1002/ijc.29003

Figure 1.

Figure 1.

Structure of HERV-K provirus. The full length (gag) HML-2 transcript encodes the gag, pro and pol polyproteins. A singly spliced transcript encodes the env polyprotein, while a doubly spliced transcript encodes either the Rec or Np9 accessory proteins depending on the presence or absence of a 292-bp deletion at the pol/env boundary–a characteristic that defines a HML-2 provirus as either Type 1 (deleted) or Type 2 (intact). HML-2 also expresses a 1.5-kb transcript of unknown function known as the hel transcript.