Table 1.
Patient demographics and electrocardiogram (ECG) parameters based on category of left ventricular ejection fraction (LVEF) in the Cedars‐Sinai Health System validation population
| Cedars‐Sinai validation populationa (n = 9,742) | |||
|---|---|---|---|
| LVEF ≤35% (n = 875) | LVEF >35% (n = 8,799) | p‐Value | |
| Demographics | |||
| Male | 648 (74%) | 4,554 (52%) | <0.001 |
| Age | 68.0 ± 16.1 | 68.7 ± 17.3 | 0.23 |
| Conventional abnormal electrocardiographic findings | |||
| Left bundle branch block (LBBB) | 101 (12%) | 266 (3%) | <0.001 |
| Atrial fibrillation/flutter | 128 (15%) | 864 (9%) | <0.001 |
| Ventricular paced rhythm | 186 (21%) | 437 (5%) | <0.001 |
| ≥1 Conventional ECG abnormality | 388 (44%) | 1,508 (17%) | <0.001 |
| Cedars‐Sinai validation population without conventional abnormal ECG findingsa (n = 7,601) | |||
|---|---|---|---|
| LVEF ≤35% (n = 461) | LVEF >35% (n = 7,140) | p‐Value | |
| Demographics | |||
| Male | 336 (73%) | 3,660 (51%) | <0.001 |
| Age | 63.8 ± 16.3 | 66.3 ± 17.4 | 0.003 |
| Expanded panel of electrocardiographic variables in subset without conventional ECG abnormalities | |||
| Heart rate >85 bpm | 215 (47%) | 2,193 (31%) | <0.001 |
| QRS >110 ms | 170 (37%) | 1,017 (14%) | <0.001 |
| Prolonged QTc ≥460 ms men and ≥470 ms women | 311 (67%) | 1,981 (28%) | <0.001 |
| QRS‐T angle >90° | 259 (56%) | 1,300 (18%) | <0.001 |
| Delayed QRS transition | 303 (66%) | 2,149 (30%) | <0.001 |
| Delayed intrinsicoid deflection | 156 (34%) | 412 (5.8%) | <0.001 |
| Left ventricular hypertrophy | 68 (15%) | 459 (6.4%) | <0.001 |
| PR >200 ms | 89 (19%) | 834 (12%) | <0.001 |
| P‐wave >110 ms | 126 (27%) | 1,303 (18%) | <0.001 |
Data are presented as n (%) or mean ± SD. All ECG parameters differed significantly between subjects with LVEF ≤35% and those with LVEF >35%.
Validation population: n = 9,742 inpatients and outpatients from the Cedars‐Sinai hospital system with LVEF assessed by echocardiogram from January 1 to December 31, 2015 and ECG available within 14 days of the echocardiogram. Conventional ECG abnormalities evaluated in n = 9,674 patients without acute myocardial infarction; expanded panel of ECG abnormalities evaluated in n = 7,601 patients without conventional abnormalities (ECGs in sinus rhythm and without LBBB).