Table 3.
AUROCs of Circulating Bone Biomarkers to Distinguish High and Low Bone Turnover from Non-high and Non-low Bone Turnover as Assessed by BFR/BS
| Blood Sample Marker | N | AUROC (95% CI) | Best Cutoff |
|---|---|---|---|
| Low vs Non-low | |||
| iPTH, pg/mL | 280 vs 196 | 0.701 (0.653–0.750) | 103.8 |
| wPTH, pg/mL | 260 vs 180 | 0.712 (0.662–0.761) | 48.0 |
| bALP, U/L | 273 vs 190 | 0.757 (0.713–0.801) | 33.1 |
| P1NP, ng/mL | 280 vs 1,197 | 0.650 (0.599–0.701) | 498.9 |
| Combined iPTH + bALP | 272 vs 188 | 0.718 (0.670–0.767) | NA |
| Combined wPTH + bALP | 257 vs 174 | 0.743 (0.695–0.790) | NA |
| High vs Non-hiah | |||
| iPTH, pg/mL | 81 vs 395 | 0.724 (0.663–0.786) | 323.0 |
| wPTH, pg/mL | 75 vs 365 | 0.678 (0.611–0.746) | 61.4 |
| bALP, U/L | 77 vs 386 | 0.711 (0.655–0.767) | 42.1 |
| P1NP, ng/mL | 81 vs 396 | 0.743 (0.689–0.797) | 621.1 |
| Combined iPTH + bALP | 76 vs 384 | 0.718 (0.658–0.779) | NA |
| Combined wPTH + bALP | 72 vs 359 | 0.691 (0.628–0.725) | NA |
Abbreviations: AUROC, area under the receiver operating characteristic curve; bALP, bone-specific alkaline phosphatase; BFR/BS, bone formation rate/bone surface; CI, confidence interval; iPTH, intact parathyroid hormone; NA, not available; P1NP, amino-terminal propeptide of type 1 procollagen; wPTH, whole parathyroid hormone. From Sprague et al, 2015. Diagnostic Accuracy of Bone Turnover Markers and Bone Histology in Patients With CKD Treated by Dialysis. Am J Kidney Dis.