. Author manuscript; available in PMC: 2019 Dec 1.

Published in final edited form as: Immunobiology. 2018 Sep 7;223(12):839–849. doi: 10.1016/j.imbio.2018.08.007

Table III.

Linear Regression Models for Potential Determinants of CD21 Expression on B cells at Baseline

Variable	Univariable Analysis			Multivariable Analysis
Variable	Coefficient	95% Confidence Interval	p-value	Coefficient	95% Confidence Interval	p-value
HIV-1 infection	−305	(−448, −162)	0.0025	−168	(−334, −2.2)	0.047
TFH activation	−7.4	(−11.0, −3.9)	0.0026	−4.1	(−8.2, −0.11)	0.045
Serum BAFF	−0.22	(−0.38, −0.058)	0.046	−0.088	(−0.23, 0.052)	0.21
+ CD4 T cell activation	−8.8	(−13.7, −4.0)	0.0086
+ CD8 T cell activation	−4.5	(−8.1, −0.88)	0.0089
IL-21 mRNA ΔCt	42	(−24.7, 108.9)	0.094

Coefficient = percent change in CD21 expression on CD19+ B cells between groups per 10% increase in T_FH, CD4, and CD8 activation (as measured by HLA-DR+, CD38+), 100pg/mL increase for BAFF, and ΔCt for IL-21 mRNA.