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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Immunobiology. 2018 Sep 7;223(12):839–849. doi: 10.1016/j.imbio.2018.08.007

Table IV.

Linear Regression Models for Potential Determinants of AID Production at Baseline

Variable Univariable Analysis Multivariable Analysis
Coefficient 95% Confidence Interval p-value Coefficient 95% Confidence Interval p-value
HIV-1 infection 45 (13.8, 110.8) 0.0025 23.9 (7.6, 75.2) 0.13
TFH activation 10.4 (10.2, 10.7) 0.0026 10.2 (9.8, 10.6) 0.15
Serum BAFF 10.0 (10.0, 10.02) 0.046 10.00 (9.99, 10.01) 0.62
CD4+ T cell activation 10.4 (10.1, 10.7) 0.0086
CD8+ T cell activation 10.3 (10.1, 10.5) 0.0089
IL-21 mRNA ΔCt 7.7 (5.7, 10.5) 0.094

Coefficient = unit change in AID ΔCt RQ between per 10% increase in TFH, CD4, and CD8 activation (as measured by HLA-DR+, CD38+), 100pg/mL increase for BAFF, and ΔCt for IL-21 mRNA.