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. Author manuscript; available in PMC: 2018 Dec 2.
Published in final edited form as: Pediatr Res. 2018 Jun 2;84(4):537–544. doi: 10.1038/s41390-018-0069-x

Figure 5. Strongest predicted causal network by IPA analysis of neonatal hearts.

Figure 5

A. Network contains differentially upregulated (green) and downregulated (red) proteins, as well as literature-inferred activation (blue) and inhibition (orange) proteins. Top functions of the genes were related to cellular proliferation, differentiation and survival. The node shapes denote triangle: kinase, fat diamond: peptidase, tall diamond: enzyme, rhomboid: transporter, oval: transcription regulator, circle: other. n=5 animals per group (1 animal per litter). B. Quantification of PARP-1 expression (RT-PCR) in whole hearts from fetal control (white bars) and MNR-FGR (black bars) animals. Data represent mean ± S.E.M. Analysis by Student’s t-test. C. Photomicrographs of papillary muscle and ventricular myocardium from control and MNR-FGR fetal hearts stained with anti-PARP1 antibody (brown) and counterstained with hematoxylin (blue). Scale bar equals 100μm.