Table 1.

Baseline characteristics of study population

Variables	Discovery set									Replication set
	Advanced colorectal neoplasia (N = 40)			Non-advanced adenoma (N = 82)			Control (N = 82)			Advanced colorectal neoplasia (N = 125)			Non-advanced adenoma (N = 72)			Control (N = 250)
	n	%	P a	n	%	P b	n	%	n		%	P a	n	%	P b	n	%
Age (years)
<60	11	27.5	1.000	23	28.0	0.980	24	29.3	42		33.6	1.000	27	37.5	0.931	84	33.6
60–64	10	25.0		21	25.6		20	24.4	34		27.2		17	23.6		66	26.4
65–69	8	20.0		14	17.1		16	19.5	24		19.2		13	18.1		49	19.6
≥70	11	27.5		24	29.3		22	26.8	25		20.0		15	20.8		51	20.4
Median (IQR)	64 (59–71)			64 (58–70)			64 (58–70)		63 (58–69)				62 (58–70)			63 (58–70)
Sex
Female	17	42.5	1.000	35	42.7	1.000	36	43.9	61		48.8	1.000	29	40.3	0.229	122	48.8
Male	23	57.5		47	57.3		46	56.1	64		51.2		43	59.7		128	51.2
Cigarette smokingc
Never	21	52.5	0.022	37	45.7	0.760	39	48.1	51		40.8	0.010	34	47.2	0.445	136	55.3
Former	10	25.0		35	43.2		36	44.4	54		43.2		32	44.4		90	36.6
Current	9	22.5		9	11.1		6	7.4	20		16.0		6	8.3		20	8.1
Alcohol intaked
Non-risky	30	78.9	0.510	52	66.7	0.490	58	72.5	76		60.8	0.047	53	73.6	0.767	178	71.2
Riskye	8	21.1		26	33.3		22	27.5	49		39.2		19	26.4		72	28.8
Red meat intakef
~1 time/day	38	95.0	1.000	77	93.9	1.000	77	93.9	119		95.2	0.150	65	92.9	0.810	223	90.7
>1 time/day	2	5.0		5	6.1		5	6.1	6		4.8		5	7.1		23	9.3
Regular use of NSAIDs
No	—	—	—	—	—	—	—	—	99		79.2	0.400	53	73.6	0.812	207	82.8
Yes	—	—		—	—		—	—	26		20.8		19	26.4		43	17.2
Family history of CRC (first-degree relative)g
No	30	75.0	0.820	63	76.8	1.000	64	78.0	100		82.0	0.070	62	86.1	0.091	219	89.0
Yes	10	25.0		19	23.2		18	22.0	22		18.0		10	13.9		27	11.0
History of colonoscopy
No	19	46.3	0.073	26	31.7	0.870	24	29.3	100		80.0	0.364	49	68.1	0.224	189	75.6
Yes	22	53.7		56	68.3		58	70.7	25		20.0		23	31.9		61	24.4
BMI (kg/m2)h, median (IQR)	26.3 (24.4–29.1)		0.496	26.3 (24.1–28.7)		0.410	25.4 (23.6–29.4)		26.6 (24.1–29.5)			0.064	26.2 (24.8–29.4)		0.064	25.9 (23.5–28.1)

^aThe difference of variables between advanced colorectal neoplasia and control was compared and two-sided P value was estimated with Fisher exact test for categorical variables and Wilcoxon rank-sum test for continuous variables

^bThe difference of variables between non-advanced adenoma and control was compared and two-sided P value was estimated with Fisher exact test for categorical variables and Wilcoxon rank-sum test for continuous variables

^cData missing in 2 and 4 subjects, respectively, in the discovery and replication sets

^dData missing in 8 subjects in the discovery set

^eAlcoholic consumption was defined as risky when a person drank >5 days per week or drank >7 (women) or >14 (men) standard alcoholic beverages per week. One standard alcoholic beverage equals a small portion of beer (0.25 l) or wine (0.1 l) or 4 cl schnapps

^fData missing in 6 subjects in the replication set

^gData missing in 7 subjects in the replication set

^hData missing in 2 and 7 subjects, respectively, in the discovery and replication sets