Fig. 3.

Indels generated during long-term niraparib treatment. a, b The mean number of short insertions (a) or short deletions (b) generated per sequenced genome in each indicated cell line following mock treatment or treatment with the indicated concentration of niraparib. Red symbols show the values for individual samples. c A classification of detected short deletion events by sequence context. The minimum length of classified microhomologies was 1 bp. Error bars indicate SEM in all panels. Significant differences are indicated (p < 0.05, unpaired t test)