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. 2018 Jul 24;37(48):6259–6274. doi: 10.1038/s41388-018-0409-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Suppression of ERRα reduces T:E fusion or ERG expression and ERG-mediated signaling in AR-positive VCaP cells. (a, c) mRNA and (b, d) protein expressions of T:E fusion/ERG in VCaP cells upon XCT790 treatment or ERRα knockdown by shRNA. Both mRNA and protein levels of T:E fusion/ERG were significantly reduced by XCT790 treatment in a dose-dependent manner (1–20 µM) and also shERRα. (e, f) mRNA levels of ERG-responsive targets were significantly suppressed by either XCT790 or shERRα. ^*P < 0.05; ^**P < 0.01 versus vehicle treatment or Scramble shRNA transfection