Table 1.
Clinical and pathoanatomic characteristics, N = 1157
| Parameter | Test cohort | Validation cohort | p-Valueb |
|---|---|---|---|
| N = 571 (%) | N = 586 (%) | ||
| Gender | |||
| Male | 282 (49) | 254 (43) | 0.0393 |
| Female | 289 (51) | 332 (57) | |
| Age, median 73 | |||
| >73 | 279 (49) | 289 (49) | 0.8768 |
| ≤73 | 292 (51) | 297 (51) | |
| T-category | |||
| T3 | 499 (87) | 507 (87) | 0.6599 |
| T4 | 72 (13) | 79 (13) | |
| Malignancy grade | |||
| Higha | 70 (12) | 116 (20) | 0.0005 |
| Medium + low | 501 (88) | 470 (80) | |
| Localisation | |||
| Right | 273 (48) | 302 (52) | 0.2052 |
| Left | 298 (52) | 284 (48) | |
| Perforation | |||
| Yes | 17 (3) | 51 (9) | 0.0001 |
| No | 529 (93) | 535 (91) | |
| NA | 25 (4) | 0 (0) | |
| Lymph nodes retrieved | |||
| ≥12 | 214 (37) | 268 (46) | 0.0072 |
| <12 | 351 (61) | 318 (54) | |
| NA | 6 (1) | 0 (0) | |
| Perineural invasion | |||
| Yes | 26 (5) | 50 (9) | 0.3312 |
| No | 358 (63) | 535 (91) | |
| NA | 187 (33) | 1 (0) | |
| Vascular invasion | |||
| Yes | 43 (8) | 69 (12) | 0.4179 |
| No | 385 (67) | 517 (88) | |
| NA | 143 (25) | 0 (0) | |
| MMR status | |||
| dMMR | 172 (30) | 170 (29) | 0.6785 |
| pMMR | 399 (70) | 416 (71) | |
| CDX2 | |||
| Positive | 346 (61) | 379 (64) | 0.1714 |
| Moderate | 159 (28) | 157 (27) | |
| Negative | 66 (12) | 50 (9) | |
Some percentages do not equal 100% due to rounding of data. Bold values are used for highlighting significant test results (p < 0.05)
MMR mismatch repair, dMMR mismatch repair-deficient, pMMR mismatch repair-proficient, CDX2 caudal-related homeobox transcription factor 2
aIncluding mucinous and sigillocellular tumours
bNot available (NA), data not included in the analyses (Chi-square statistics)