Table 3.
Breast cancer characteristics of all women and by denosumab use
| Variable, n (%) unless otherwise noted | Value | Total | No denosumab | Denosumab | P |
|---|---|---|---|---|---|
| N=1238 (%) | N=957 (%) | N=281 (%) | |||
| Diagnosis year | 2012 | 47 (4) | 37 (4) | 10 (4) | 0.14 |
| 2013 | 117 (9) | 81 (8) | 36 (13) | ||
| 2014 | 177 (14) | 139 (15) | 38 (14) | ||
| 2015 | 263 (21) | 205 (21) | 58 (21) | ||
| 2016 | 376 (30) | 284 (30) | 92 (33) | ||
| 2017 | 258 (21) | 211 (22) | 47 (17) | ||
| Stage | Unknown | 307 (25) | 242 (25) | 65 (23) | |
| I | 405 (44) | 316 (44) | 89 (41) | 0.28 | |
| II | 350 (38) | 267 (37) | 83 (38) | ||
| III | 113 (12) | 80 (11) | 33 (15) | ||
| IV | 63 (7) | 52 (7) | 11 (5) | ||
| Tumor size (continuous) (cm) | Mean±SD | 2.6±2.0 | 2.6±2.0 | 2.7±2.0 | 0.50 |
| Median (IQR) | 2 (1–3) | 2 (1–3) | 2 (1–4) | 0.45 | |
| Tumor size (categorical) (cm) | Unknown | 532 (43) | 428 (45) | 104 (37) | |
| <1 cm | 103 (15) | 75 (14) | 28 (16) | 0.57 | |
| 1–2 cm | 222 (31) | 174 (33) | 48 (27) | ||
| 2–3 cm | 161 (23) | 120 (23) | 41 (23) | ||
| 3–5 cm | 145 (21) | 108 (20) | 37 (21) | ||
| 5+ cm | 75 (11) | 52 (10) | 23 (13) | ||
| Nodes involved (continuous) | Mean±SD | 0.7±2.2 | 0.6±1.6 | 1.1±3.3 | 0.03 |
| Median (IQR) | 0 (0–1) | 0 (0–1) | 0 (0–1) | 0.37 | |
| Nodes involved (categorical) | Unknown | 640 (52) | 509 (53) | 131 (47) | |
| Node negative | 421 (70) | 317 (71) | 104 (69) | 0.74 | |
| Node positive | 177 (30) | 131 (29) | 46 (31) | ||
| Grade | Unknown | 651 (53) | 522 (55) | 129 (46) | |
| Low grade | 126 (21) | 94 (22) | 32 (21) | 0.98 | |
| Medium grade | 306 (52) | 227 (52) | 79 (52) | ||
| High grade | 155 (26) | 114 (26) | 41 (27) | ||
| ER status | Unknown | 574 (46) | 462 (48) | 112 (40) | |
| Negative | 89 (13) | 64 (13) | 25 (15) | 0.54 | |
| Positive | 575 (87) | 431 (87) | 144 (85) | ||
| PR status | Unknown | 582 (47) | 467 (49) | 115 (41) | |
| Negative | 158 (24) | 117 (24) | 41 (25) | 0.83 | |
| Positive | 498 (76) | 373 (76) | 125 (75) | ||
| HER2 status | Unknown | 602 (49) | 477 (50) | 125 (44) | |
| Borderline | 165 (26) | 127 (26) | 38 (24) | 0.62 | |
| Negative | 417 (66) | 315 (66) | 102 (65) | ||
| Positive | 54 (8) | 38 (8) | 16 (10) |