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. 2018 Nov 23;9:2732. doi: 10.3389/fimmu.2018.02732

Figure 2.

Figure 2

Loss of HuR in IECs –but not in myeloid cells- sensitizes the epithelium to acute inflammatory death signals. (A) Representative H&E histology of paraffin embedded intestines from control and HuR mutant mice exposed either to aCD3 or isotype IgG for the indicated times. (B) Quantification of villus/crypt length ratio, colonic crypt height and histological score of IEC-HuRko treated mice (upper panel) and M-HuRko mice (lower panel). n = 3–6/group/time point. Student unpaired t-test. (C) (left panels) Enumeration of cells expelled in lumen washes from the intestines of mice exposed to aCD3 or IgG control. (right panels) Flow cytometric determination of apoptotic cell numbers of the same exudates, analyzed 6 and 24 h post injections in IEC-HuRko (upper panel), M-HuRko (lower panel) mice and respective controls. n = 3–6/genotype/time point. Student unpaired t-test. All bar graphs show means (±SE). In all graphs, *,****, denote p-values < 0.05 and 0.0001 respectively.