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. 2018 Nov 23;9:1364. doi: 10.3389/fphar.2018.01364

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Copyright © 2018 Zhang, Wei, Zhang, Fu, Mi, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of TSPO overexpression in the DG on the number of BrdU-positive cells in the hippocampus in mice after electric foot-shocks. (A) A confocal laser-scanning microscope micrographs of BrdU-labeled cells (red) in the dentate gyrus of hippocampus. Scale bar = 200 μm. (B) NeuN (green) and BrdU (red) co-labeled cells in the dentate gyrus were photographed and quantified under confocal microscope. Scale bar = 50 μm. (C) Statistical analysis showed a significant decrease of the number of BrdU-positive cells in mice of foot-shock exposure (LV-NC + FS) compared with non-foot-shocked mice (Lv-NC), whereas it was prevented in the group of Lenti-GFP-TSPO injection (Lv-TSPO +FS). The improvement of Lv-TSPO was reversed by PK11195 (Lv-TSPO + PK11195 +FS). Data were presented as the means ± SEM (n = 3). ^∗P < 0.05 compared with the Lv-N+foot-shock (–) group; ^#P < 0.05 compared with the Lv-NC+FS group; ^$P < 0.05 compared with the Lv-TSPO+FS group. ^##P < 0.01 compared with the Lv-NC+FS group.