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. 2018 Sep 4;46(21):11239–11250. doi: 10.1093/nar/gky789

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Comparison of GM12878 and IMR90 from the CDB view. (A) Aggregation of Hi-C maps centered on the differential CDBs. Hi-C maps show a gain of insulation at the cell-type-specific CDBs. (B) Cell-type-specific CDBs enriched in cell-type-specific active regulatory signals. (C) The fold change distributions of the differential expressed genes near differential CDBs. P value is calculated using Wilcoxon rank-sum test. (D) A differential region (chr9:36.50–37.50 Mb) between GM12878 and IMR90 detected by HiCDB. This region possesses a B cell important regulator, PAX5, which is not expressed in IMR90. E1-E3 marks three potential enhancers of PAX5 detected by HiCDB other than HiCCUPs. The IMR90 POLR2A- and CTCF-mediated loops are not shown because the ChIA-PET data are not currently available, while the Hi-C loops are not shown because no Hi-C loops were detected on the IMR90 Hi-C map in this region.