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. 2018 Aug 22;46(21):11202–11213. doi: 10.1093/nar/gky754

Figure 2.

Figure 2.

Overexpression of DYRK1A leads to hyper-phosphorylation of CBP and p300. (A) Whole cell lysates from 293T cells co-transfected with Myc-p300 and Flag-DYRK1A-WT or Flag-DYRK1A-KD were treated with λ phosphatase, and analysed by western blot. Arrows indicate the slower migrating p300 signal in vector vs DYRK1A overexpression. (B) Whole cell lysates from 293T cells co-transfected with HA-CBP and Flag-DYRK1A-WT or Flag-DYRK1A-KD were treated with λ phosphatase, and analysed by western blot. Arrows indicate the slower migrating CBP signal in vector vs DYRK1A overexpression.