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. 2018 Aug 22;46(21):11202–11213. doi: 10.1093/nar/gky754

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — DYRK1A is required for p300/CBP mediated H3K27 acetylation at its target enhancers (A–C) ChIP analysis of DYRK1A, H3K27acetylation and CBP in cells treated with control or DYRK1A shRNA. DYRK1A bound enhancer sites (near DNAJC12, DYNC1H1 and WNT11) and at TSS (RPS6 and CDK12) were probed for enrichment. (D–F) ChIP analysis of CBP, H3K27acetylation and DYRK1A in cells treated with control or CBP shRNA. Sites probed as in (A–C). Data represent the mean ± SD (n = 3 biological replicates). Student's t test were done to compare samples. P value = * (P < 0.05).