Table 1.

Comparison of zebrafish and rodent models in Alzheimer’s disease research.

Zebrafish	Rodents
Zebrafish advantegeous over rodents
Amyloid-mediated neuronal death	No neuronal death
Neuroregenerative capacity	No neuroregenerative capacity
Stem cell plasticity for neurogenesis	Stem cells reduce plasticity and neurogenesis
Cost efficient generation and maintenance	Expensive generation and maintenance
High number of animals testable	Limited number of animals testable
3R strategies developed	3R strategies to be developed
Zebrafish and rodents equal
Synaptic degeneration	Synaptic degeneration
Cognitive decline with Amyloidosis	Cognitive decline with Amyloidosis
Genetic tools available	Genetic tools available
Does not reflect the entire biology of the human disease	Does not reflect the entire biology of the human disease
Rodents advantegeous over zebrafish
Non-mammalian physiology	Mammalian physiology
Need for adaptation to preclinical studies	Suitable for preclinical studies
Limited number of models expressing disease-related proteins	Variety of models expressing disease-related proteins