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. 2018 Nov 23;9:703. doi: 10.3389/fendo.2018.00703

Figure 1.

Figure 1

Chronic SGE-516 treatment decreases depression-like behaviors and improves maternal care in preclinical PPD models. Chronic treatment with SGE-516 (450 mg/kg chow, ~7 d) increases the average latency to immobility and decreases the total time spent immobile in postpartum Gabrd−/− (A), Gabrd+/− (B), and KCC2/Crh dams (C) in the forced swim test. *Denotes statistical significance of p < 0.05 using a Student's t-test. Chronic treatment with SGE-516 (450 mg/kg chow, ~7 d) decreases the average latency to approach their pups and increases to total interaction time with the pups in postpartum Gabrd−/− (D), Gabrd+/− (E), and KCC2/Crh dams (F) in the maternal approach test. *Denotes statistical significance of p < 0.05 using a Student's t-test.