Table 1.

Pharmacological treatments and exposure levies.

Experiment	Dose	Route of administration	Plasma levels (ng/ml)	Brain levels (ng/g)	n numbers
Vehicle	standard chow	oral (chow)	nd	nd	2
Chronic SGE-516	450 mg/kg chow	oral (chow)	72.5 ± 17.4	86.6 ± 211	4
Chronic clobazam	250 mg/kg chow	oral (chow)	54.3 ± 9.9	73.1 ± 11.9	9
Vehicle	5%HPβCD	i.p.	nd	nd	2
Acute SGE-516	5mg/kg	i.p.	415.0 ± 174.8	669.8 ± 265.4	4
Arute Clobazam	10mg/kg	i.p.	94.1 ± 18.6	180.6 ± 27.9	5

i.p., Intraperitoneally; nd, not detected.