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. 2018 Nov 23;9:703. doi: 10.3389/fendo.2018.00703

Table 1.

Pharmacological treatments and exposure levies.

Experiment Dose Route of administration Plasma levels (ng/ml) Brain levels (ng/g) n numbers
Vehicle standard chow oral (chow) nd nd 2
Chronic SGE-516 450 mg/kg chow oral (chow) 72.5 ± 17.4 86.6 ± 211 4
Chronic clobazam 250 mg/kg chow oral (chow) 54.3 ± 9.9 73.1 ± 11.9 9
Vehicle 5%HPβCD i.p. nd nd 2
Acute SGE-516 5mg/kg i.p. 415.0 ± 174.8 669.8 ± 265.4 4
Arute Clobazam 10mg/kg i.p. 94.1 ± 18.6 180.6 ± 27.9 5

i.p., Intraperitoneally; nd, not detected.