Table 2.
Acute and Chronic SGE-516 treatment improves abnormal postpartum behaviors in two preclinical PPD models.
| Genotype | Treatment | Latency to immobility | Total time immobile | n | Latency to approach | Total interaction time | n |
|---|---|---|---|---|---|---|---|
| Wild Type | Standard Chow | 82.2 ± 7.9 s | 131.3 ± 14.3 s | 9 | 54.2 ± 12.6 s | 1408.2 ± 187.2 s | 8 |
| Gabrd−/−dams | Standard Chow | 59.5 ± 3.2 s# | 215.7 ± 11.1 s# | 10 | 697.5 ± 197.3 s# | 429.7 ± 177.8 s# | 10 |
| Gabrd−/−dams | Chronic SGE-516 (450 mg/kg chow) | 124.8 ± 23.0 s* | 92.3 ± 15.4 s* | 9 | 58.6 ± 33.0 s* | 1411.9 ± 219.3 s | 7 |
| Gabrd−/−dams | Standard Chow | 54.3 ± 8.6 s# | 227.6 ± 18.7 s# | 7 | 752.9 ± 167.7 s# | 376.4 ± 151.2 s# | 12 |
| Gabrd−/−dams | Chronic Clobazam (250 mg/kg chow) | 54.4 ± 6.9 s | 236.9 ± 8.3 s | 9 | 405.0 ± 143.6 s | 133.6 ± 34.1 s | 7 |
| Gabrd+/−dams | Standard Chow | 57.5 ± 7.8 s# | 207.1 ± 10.4 s# | 12 | 580.5 ± 226.7 s# | 529.5 ± 125.8 s# | 11 |
| Gabrd+/−dams | Chronic SGE-516 (450 mg/kg chow) | 112.0 ± 28.4 s* | 113.5 ± 18.5 s* | 10 | 57.8 ± 17.6 s* | 1081.0 ± 168.4 s* | 9 |
| KCC2/Crh | Standard Chow | 59.5 ± 8.1 s# | 207.8 ± 15.3 s# | 10 | 602.1 ± 162.5 s# | 301.0 ± 96.4 s# | 14 |
| KCC2/Crh | Chronic SGE-516 (450 mg/kg chow) | 95.9 ± 11.2 s* | 125.7 ± 12.4 s* | 17 | 229.2 ± 129.9 s* | 973.9 ± 169.6 s* | 13 |
| KCC2/Crh | Standard Chow | 54.5 ± 7.6 s# | 217.8 ± 15.2 s# | 10 | 655.5 ± 147.7 s# | 310.9 ± 86.1 s# | 11 |
| KCC2/Crh | Chronic Clobazam (250 mg/kg chow) | 40.0 ± 6.3 s | 241.1 ± 7.2 s | 8 | 801.4 ± 223.6 s | 310.7 ± 127.6 s | 7 |
| Gabrd−/−dams | Vehicle | 62.8 ± 5.7 s | 233.4 ± 18.2 | 9 | 901.4 ± 195.3 s | 358.4 ± 141.3 s | 11 |
| Gabrd−/−dams | Acute SGE-516 (5 mg/kg) | 85.4 ± 4.9 s* | 175.0 ± 15.7 s* | 12 | 143.3 ± 96.2 s* | 725.0 ± 166.8 s* | 9 |
| Gabrd−/−dams | Vehicle | 56.3 ± 8.1 s | 218.5 ± 15.6 s | 8 | 774.4 ± 207.1 s | 317.1 ± 163.3 s | 8 |
| Gabrd −/−dams | Acute Clobazam (10 mg/kg) | 59.4 ± 5.0 s | 253.4 ± 5.0 s | 9 | 1143.5 ± 242.8 s | 152.0 ± 73.8 s | 10 |
| KCC2/Crh | Vehicle | 60.9 ± 6.9 s | 221.2 ± 15.2 s | 11 | 791.3 ± 191.2 s | 232.3 ± 94.2 s | 16 |
| KCC2/Crh | Acute SGE-516 (5 mg/kg) | 94.5 ± 9.5 s* | 154.2 ± 17.0 s* | 11 | 108.3 ± 66.1 s* | 723.1 ± 129.6 s* | 9 |
| KCC2/Crh | Vehicle | 61.9 ± 9.2 s | 206.0 ± 18.3 s | 8 | 884.3 ± 249.2 s | 258.5 ± 139.3 s | 10 |
| KCC2/Crh | Acute Clobazam (10 mg/kg) | 55.5 ± 9.3 s | 252.7 ± 9.2 s | 10 | 806.9 ± 206.1 s | 398.8 ± 190.3 s | 8 |
#
Denotes p < 0.05 compared to Wild Type mice treated with vehicle or standard chow;
*
Denotes p < 0.05 compared to vehicle or standard chow treated mice within genotype.