Table 1.
No. | Treatment from day 1 to day 7 | Treatment on day 7th, 45 min after administration of the last dose |
---|---|---|
G-I (Normal Control) | Normal saline 10 ml/kg/p.o. | – |
G-II (Amnesic Control) | 5% CMC 10 ml/kg/p.o. | Scopolamine (10 mg/kg/p.o.) |
G-III (Standard Control-A) | Piracetam 200 mg/kg/p.o. | – |
G-IV (Standard Control-B) | Piracetam 200 mg/kg/p.o. | Scopolamine (10 mg/kg/p.o.) |
G-V (Experimental Control-I) | meL.s 200 mg/kg/p.o. | Scopolamine (10 mg/kg/p.o.) |
G-VI (Experimental Control-II) | meL.s 400 mg/kg/p.o. | Scopolamine (10 mg/kg/p.o.) |
G-VII (Experimental Control-III) | meL.s 800 mg/kg/p.o. | Scopolamine (10 mg/kg/p.o.) |
Scopolamine and piracetam were dissolved in normal saline while L. stoechas was suspended in 5% CMC for dose preparation. Then animals were subjected to elevated plus maze (EPM), light and dark test apparatus and hole board test apparatus for behavioral assessment.