Table 2.

Gaps in our knowledge that can be filled using guinea pig models

Current uses of guinea pig models in DOHaD	What the guinea pig model can offer in future DOHaD studies
DOHaD models of common, clinically important conditions have been established in guinea pigs that result in similar outcomes as in humans	The commonality in physiology between guinea pigs and humans can be exploited much more aggressively in studies of reproductive toxicology, maternal medication exposure and therapeutic fetal interventions
Safety and efficacy studies of novel therapeutic interventions have been tested in guinea pigs and their results used to inform the development of human studies	Guinea pigs can enable assessments of long term outcomes, including multi‐ and trans‐generational outcomes as well as a rigorous assessment of the paternal contribution to DOHaD