Table 3.
Animal losses during experimental procedures
| CON | FGR | FGRS | FGRI | |
|---|---|---|---|---|
| Prenatal losses | ||||
| Experimentally induced | — | 12 | 26 | 21 |
| Catheter tangles | — | 0 | 3 | 0 |
| Congenital defect | — | 3● | 2● | 3● |
| Intrauterine infection | — | 2 | 0 | 2 |
| Stillbirth | — | 0 | 1 | 2 |
| Early postnatal losses | ||||
| Experimental complications | 0 | — | 1‡ | 1‡, 1¥ |
| Illness | 0 | — | 1† | 1† |
| Congenital defect | 0 | — | 1* | 0 |
Congenital defects were observed during the prenatal (●, brachycephaly) and postnatal (*, intestinal atresia) experimental period in fetal growth restricted (FGR) lambs prior to randomisation to experimental groups, saline‐treated fetal growth restricted (FGRS), and insulin‐like growth factor 1‐treated fetal growth restricted (FGRI) lambs. Control (CON) lambs did not undergo instrumentation. Early postnatal losses include respiratory distress and/or congenital heart failure secondary to pulmonary aneurysm (†), and experimental complications (‡, liver biopsy; ¥, anaesthesia).