Table 7.
Plasma corticosteroids and thyroid hormones in the first week after birth
| Female | Male | P values for treatment effect | ||||||
|---|---|---|---|---|---|---|---|---|
| CON | FGRS | FGRI | CON | FGRS | FGRI | |||
| n = 11–15 | n = 10–13 | n = 10–12 | n = 12—16 | n = 10‐11 | n = 9–10 | Female | Male | |
| Day 1 | ||||||||
| Cortisol (ng mL−1) | 70.1 ± 9.9 | 59.5 ± 9.5 | 52.5 ± 9.5 | 72.0 ± 25.8 | 64.3 ± 22.8 | 80.5 ± 24.2 | ns | ns |
| Cortisone (ng mL−1) | 20.0 ± 5.6 | 22.2 ± 5.8 | 15.8 ± 5.8 | 20.1 ± 7.0 | 16.8 ± 6.8 | 21.7 ± 7.0 | ns | ns |
| ln 11‐deoxycortisol | −0.8 ± 0.2 | −1.2 ± 0.2 | −1.1 ± 0.2 | −0.8 ± 0.6 | −1.0 ± 0.3 | −0.6 ± 0.4 | ns | ns |
| ln cortisol:cortisone ratio | 1.4 ± 0.2 | 1.5 ± 0.2 | 1.4 ± 0.2 | 1.4 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | ns | ns |
| Cortisol:11‐deoxycortisol ratio | 155 ± 42 | 183 ± 45 | 123 ± 45 | 187 ± 16 | 144 ± 29 | 170 ± 33 | ns | ns |
| T3 (pg mL−1) | 17.5 ± 1.7 | 14.0 ± 1.9 | 14.7 ± 2.2 | 18.0 ± 2.9 | 13.3 ± 2.9 | 11.9 ± 3.0 | ns | 0.04† |
| T4 (pmol mL−1) | 73.0 ± 4.5 | 49.7 ± 5.8 | 44.4 ± 7.5 | 59.3 ± 1.06 | 56.1 ± 10.4 | 49.8 ± 10.6 | <0.01*† | ns |
| ln T3:T4 tatio | −1.4 ± 0.1 | −1.3 ± 0.1 | −1.2 ± 0.1 | −1.2 ± 0.1 | −1.4 ± 0.1 | −1.5 ± 0.1 | ns | ns |
| Day 7 | ||||||||
| Cortisol (ng mL−1) | 31.2 ± 8.8 | 39.2 ± 9.9 | 22.4 ± 9.8 | 25.5 ± 4.6 | 48.4 ± 8.3 | 31.7 ± 9.4 | ns | ns |
| Cortisone (ng mL−1) | 8.3 ± 1.3 | 8.1 ± 1.5 | 5.5 ± 1.5 | 8.2 ± 0.7 | 10.8 ± 1.3 | 7.4 ± 1.5 | ns | ns |
| ln 11‐deoxycortisol | −1.3 ± 0.5 | −0.9 ± 1.2 | −1.6 ± 1.3 | −1.3 ± 0.4 | −0.7 ± 0.4 | −0.8 ± 0.5 | ns | ns |
| ln cortisol:cortisone ratio | 1.6 ± 0.2 | 1.8 ± 0.2 | 1.9 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.9 ± 0.1 | ns | ns |
| Cortisol:11‐deoxycortisol ratio | 98.5 ± 16.9 | 76.0 ± 19.4 | 80.6 ± 19.2 | 73.4 ± 15.7 | 76.7 ± 14.0 | 65.1 ± 15.4 | ns | ns |
| T3 (pg mL−1) | 16.0 ± 0.6 | 16.7 ± 0.7 | 16.1 ± 0.7 | 15.7 ± 1.3 | 15.6 ± 1.2 | 14.5 ± 1.3 | ns | ns |
| T4 (pmol mL−1) | 45.2 ± 1.1 | 44.0 ± 1.3 | 36.8 ± 1.2 | 41.2 ± 2.6 | 39.5 ± 2.4 | 36.3 ± 2.6 | <0.0001*‡ | ns |
| ln T3:T4 ratio | −1.5 ± 0.1 | −1.1 ± 0.1 | −1.1 ± 0.1 | −1.2 ± 0.1 | −1.2 ± 0.1 | −1.2 ± 0.1 | ns | ns |
Absolute plasma corticosteroids and thyroid hormones, natural log transformation (ln) of plasma corticosteroids and thyroid hormones and ratios at birth (Day 1) and 7 days after birth. l‐3,3′,5‐triiodothyronine (T3), thyroxine (T4). Data are means ± SEM. Symbols denote significant differences amongst experimental groups upon post hoc testing: *CON vs. FGRS; †CON vs. FGRI; ‡FGRS vs. FGRI; ns, not significant.