Table 1.
Body weight, food and energy intake and organ weights
| Normal salt (0.52%) | High salt (8%) | Two‐way ANOVA | ||||
|---|---|---|---|---|---|---|
| Control | Restricted | Control | Restricted | Diet | Restricted | |
| Body weight (g) | ||||||
| Before high salt diet – age | ||||||
| P6 | 9.1 ± 0.3 | 7.5 ± 0.5 | 8.5 ± 0.4 | 7.1 ± 0.3 | NS | P < 0.05 |
| P14 | 22.3 ± 0.5 | 18.9 ± 1.1 | 20.9 ± 0.7 | 18.1 ± 1.6 | NS | P < 0.05 |
| P35 | 82 ± 2 | 72 ± 3 | 80 ± 2 | 72 ± 4 | NS | P < 0.05 |
| 8 weeks | 162 ± 4 | 135 ± 8 | 165 ± 5 | 133 ± 7 | NS | P < 0.05 |
| 12 weeks | 293 ± 6 | 261 ± 9 | 288 ± 4 | 251 ± 9 | NS | P < 0.05 |
| 16 weeks | 358 ± 6 | 323 ± 9 | 352 ± 4 | 305 ± 12 | NS | P < 0.05 |
| 20 weeks | 365 ± 7 | 336 ± 10 | 365 ± 5 | 314 ± 13 | NS | P < 0.05 |
| During high salt diet – age | ||||||
| 23 weeks | 388 ± 5 | 348 ± 9 | 365 ± 6 | 318 ± 14 | P < 0.05 | P < 0.05 |
| 25 weeks | 399 ± 5 | 368 ± 10 | 377 ± 6 | 325 ± 13 | P < 0.05 | P < 0.05 |
| 26 weeks (i.e. study end) | 405 ± 7 | 370 ± 12 | 380 ± 6 | 327 ± 13 | P < 0.05 | P < 0.05 |
| Total weight gained | 40.6 ± 2.8 | 34.0 ± 4.4 | 15.1 ± 2.5 | 13.1 ± 2.8 | P < 0.05 | NS |
| Food intake (g 24 h−1) | ||||||
| Before high salt diet (i.e. 8 weeks of age) | 19.9 ± 0.9 | 16.4 ± 0.9 | 19.4 ± 1.0 | 17.2 ± 1.6 | NS | P < 0.05 |
| At 6 weeks of high salt diet (i.e. 26 weeks of age) | 17.6 ± 1.3 | 19.1 ± 1.9 | 19.2 ± 1.0 | 17.4 ± 1.2 | NS | NS |
| Energy intake (kJ 24h−1) | ||||||
| At 6 weeks of high salt diet (i.e. 26 weeks of age) | 246 ± 18 | 268 ± 26 | 248 ± 12 | 224 ± 15 | NS | NS |
| Salt intake (g 24h−1) | ||||||
| At 6 weeks of high salt diet (i.e. 26 weeks of age) | 0.092 ± 0.007 | 0.100 ± 0.010 | 1.537 ± 0.077 | 1.388 ± 0.092 | P < 0.05 | NS |
| Organ weight (mg mm leg length−1) | ||||||
| At 6 weeks of high salt diet (i.e. 26 weeks of age) | ||||||
| Heart | 26.2 ± 0.4 | 24.2 ± 0.6 | 28.1 ± 0.7 | 25.7 ± 1.0 | P < 0.05 | P < 0.05 |
| Left ventricle | 18.8 ± 0.6 | 18.4 ± 0.4 | 20.3 ± 0.9 | 19.3 ± 0.9 | NS | NS |
| Left kidney | 25.4 ± 1.0 | 23.2 ± 0.6 | 28.5 ± 0.7 | 25.2 ± 1.2 | P < 0.05 | P < 0.05 |
| Liver | 222 ± 6 | 204 ± 5 | 207 ± 5 | 192 ± 7 | P < 0.05 | P < 0.05 |
| Pancreas | 12.5 ± 0.9 | 13.2 ± 0.9 | 13.9 ± 1.3 | 12.7 ± 1.3 | NS | NS |
| Dorsal fat | 87.3 ± 11.2 | 64.0 ± 6.2 | 57.6 ± 4.3 | 40.3 ± 6.9 | P < 0.05 | P < 0.05 |
| Leg length (mm) | 53.2 ± 0.4 | 51.4 ± 0.5 | 53.0 ± 0.5 | 50.6 ± 0.7 | NS | P < 0.05 |
Control and Restricted rats were randomized to normal salt or high salt diet for 6 weeks at 20–26 weeks of age. No significant interactions between diet and uteroplacental insufficiency surgery by two‐way ANOVA; n = 7–11 per group. NS, not significant.