Table 2.
Comparison of Slc gene expression in developing mouse and rat brain endothelial cells and choroid plexus epithelial cells
| Family | Transporter function | Choroid plexus epithelial cells | Present in both cell types | Cerebral endothelial cells |
|---|---|---|---|---|
| Slc1 | High affinity glutamate and neutral AA transporter | — | a3, a4, a5 | a1, a4rg‐ps, a2, a6 |
| Slc2 | GLUT‐1 transporter | — | a1, a3, a4, a5, a6, a8, a10, a12, a13 | a9 |
| Slc3 | Heavy subunits of heterodimeric AA transporters | ra1 | a2 | |
| Slc4 | Bicarbonate transporter | a1 | a2, a3, a4, a5, a8, a10, a11 | a7, a1ap |
| Slc5 | Na+/glucose co‐transporter | a1, ra8, ra10 | a3, a5, a7, a6, a10 | a3 |
| Slc6 | Na+‐ and Cl−‐dependent Na+/neurotransmitter symporters | a11, a13, a14, a15, a20b | a1, a4, a6, a8, a9, a13, a15, a17, a20a | a2, a1, a7, a11, a20a |
| Slc7 | Cationic AA transporter/glycoprotein‐associated | a2, a7,a10, a11, ra3, ra12 | a1, a5, a6, a7, a10, a11, | a3, a4, a8 a2, a14, a6os |
| Slc8 | Na+/Ca2+ exchanger | — | a1, a3 | a2 |
| Slc9 | Na+/H+ exchanger | ra3 | a1, a2, a3r1, a3r2, a5, a6, a7, a8, a9 | — |
| Slc10 | Sodium bile salt co‐transport | — | a3, a4, a6 | a7 |
| Slc11 | Proton coupled metal ion transport | — | a2, a1 | — |
| Slc12 | Electroneutral cation/Cl− co‐transporter | ra1, ra3 | a2, a4, a6, a7, a8, a9 | a5 |
| Slc13 | Na2SO4/carboxylate co‐transporter | — | a4, a5 | a3 |
| Slc14 | Urea transporter | a2_v1 | a2 | — |
| Slc15 | Proton oligopeptide co‐transporter | — | a2, a3 | a4 |
| Slc16 | Monocarboxylate transporter | ma3 | a1, a2, a3, a4, a6, a7, a8, a9, a10, a12, a13, a14 | a11 |
| Slc17 | Vesicular glutamate transporter | a6, ra9 | a5‐8 | — |
| Slc18 | Synaptic vesicular amine transporter | — | a2 | a3 |
| Slc19 | Folate/thiamine transporter | — | a1‐3 | |
| Slc20 | Na+/PO4 3− co‐transporter | — | a1, a2 | — |
| Slco | Organic anion transporter | m1a5, m5a1 | 1a4, 1c1, 2a1 | 2b1, 3a1, 4a1, 5a1 |
| Slc22 | Organic cation/anion/zwitterion transporter | a6, a23, ma17, ma21, ra2, ra7, ra9, ra18, ra25 | a5, a17, a18, a8, a12, a15 | a2, a3, a4, a21, a23, |
| Slc23 | Na+‐dependent ascorbic acid transporter | ra3 | a2, ra1 | |
| Slc24 | Na+/(Ca2+/K+) exchanger | a3 | a4, a5, a6 | a2 |
| Slc25 | Mitochondrial carriers | a18, a21, ra31‐32, ra40, ra44, ra46 | a1, a3, a4, a5, a10, a12, a14, a15, a16, a17, a20, a22, a24, a26, a27, a28, a29, a30, a32, a33, a35 a37, a38, a39, a45 | a2, a11, a13, a18, a19, a23, a25, a34, a36, a40, a42, a44, a46, a47, a51, a53 |
| Slc26 | Multifunctional anion exchanger | a7, ra3‐4 | a2 | a6, a1, a7, a10, a11 |
| Slc27 | Fatty acid transport | ma2, ma3 | a1, a3, a4, a6 | a4, a2 |
| Slc28 | Na+‐coupled nucleoside transport | a3, ra2 | — | — |
| Slc29 | Facilitative nucleoside transporter | a2 | a4, a2, ra3 | a1 |
| Slc30 | Zn2+ efflux | ma10, ra2 | a3, a4, a5, a6, a9, ra10 | a1, a7 |
| Slc31 | Cu2+ transporter | — | a1, a2 | — |
| Slc32 | Vesicular inhibitory amino acid transporter | — | ra1 | — |
| Slc33 | Acetyl‐CoA transporter | ma1 | ra1 | — |
| Slc34 | Sodium‐dependent phosphate transport protein 2B | ra2 | — | — |
| Slc35 | Nucleoside‐sugar transporter | e2, f1, f3 | a1, a2, a3, a4, d2, e4, f2, f5 | a5, b1, b2, e1, e3 |
| Slc36 | Proton‐coupled AA transporter | — | a1, a4 | |
| Slc37 | Sugar‐phosphate/phosphate exchanger | a1, a2 | a3, a4 | |
| Slc38 | Sodium‐coupled neutral AA transporter | ma4, a11, ra1, ra7, ra8 | a1, a3, a5, a4 | a2, a6, a7, a9 |
| Slc39 | Metal ion transporter | ma4, ma12 | a8, a10, a11, a14, a1, a3, a7,a12, a13 | a6, a5, a9, a10, a14 |
| Slc40 | Basolateral Fe2+ transporter | a1 | — | |
| Slc41 | Mg2+ transporter | — | a1, a2 | a3 |
| Slc43 | Na+‐independent, AA transporter | ma1, ma2 | ra1, ra2, ra3 | — |
| Slc44 | Choline‐like transporter | a3, ra4 | a1 | a2, a5 |
| Slc45 | Sugar transporter | — | a4, a1, a3 | a2 |
| Slc46 | Folate transporter | a1 | a3 | — |
| Slc47 | Multidrug and toxin extrusion protein 1 | a1 | — | — |
| Slc48 | Heme transporter | a1 | — | a1 |
| Slc50 | Sugar efflux | ma1 | — | a1 |
| Slc52 | Novel riboflavin transporter family | — | — | a2 |
Data from Affymetrix mouse genechip arrays for choroid plexus (E15, Liddelow et al. 2011a) and cerebral endothelial cells (Daneman et al. 2010a). Data from RNA‐Seq Saunders et al. (2015a) rat E15 choroid plexus; Whish et al. (2015) E17 mouse ventricular zone (would have contained transcripts from endothelial and non endothelial cells). Transcripts that were present at both the blood–CSF and blood–brain barriers are shown in middle column. Transcripts that are present only in cerebral endothelial cells and not peripheral endothelial cells are underlined. AA, amino acid; m, mouse only; r, rat only.