Figure 1. The physiological effects of cerebral ischaemia for 30 min (from time zero), with or without cerebral cooling (indicated with the blue bar) induced from 3 until 72 h after reperfusion in term‐equivalent fetal sheep.

The panels show, in descending order, temporal changes in extradural temperature (°C), cortical impedance (i.e. cellular swelling, as a percentage from baseline), and electroencephalographic (EEG) power (decibels) in normothermia (black circles) and hypothermia groups (blue circles), compared to sham‐ischaemic animals (white circles). Treatment with hypothermia suppressed the delayed rise in cytotoxic oedema (as measured with cortical impedance), and improved recovery of EEG power after resolution of the secondary seizures.