Table 4. Subgroup analysis of rs226794, rs2830585 and risk of musculoskeletal degenerative diseases.
| Variant | Subgroup | Category | No. of studies | OR (95%CI) | P-value | Test for heterogeneity |
|---|---|---|---|---|---|---|
| Rs226794 | Ethnicity | Asian | 3 | 1.05 (0.93, 1.20) | 0.42 | P=0.51, I2 = 0% |
| Caucasian | 4 | 1.11 (0.95, 1.29) | 0.21 | P=0.87, I2 = 0% | ||
| Type of disease | OA | 6 | 1.12 (0.99, 1.26) | 0.06 | P=0.98, I2 = 0% | |
| LDD | 1 | 0.98 (0.81, 1.17) | 0.79 | NA | ||
| Rs2830585 | Ethnicity | Asian | 2 | 1.41 (1.18, 1.68) | 0.0001 | P=0.80, I2 = 0% |
| Caucasian | 2 | 0.82 (0.65, 1.02) | 0.07 | NA | ||
| Type of disease | OA | 3 | 1.10 (0.94, 1.27) | 0.23 | P=0.001, I2 = 85% | |
| LDD | 1 | 1.36 (0.98, 1.88) | 0.07 | NA |
95%CI: 95% confidence interval; LDD: lumbar disc degeneration; NA: not available; OA: osteoarthritis; OR: odds ratio.
Statistically significant results were highlighted in bold.