Table 1. Basic information for included studies of the association between three KLK3 polymorphisms and prostate cancer susceptibility.
| Author [Ref.] | Year | Origin | Ethnicity | Source | Case | Control | Case | Control | HWE | Age range | Method | NOS | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | ||||||||||||||||
| rs2735839 | GG | GA | AA | GG | GA | AA | |||||||||||
| Hu [15] | 2014 | China | Asian | PB | 108 | 242 | 25 | 68 | 15 | 44 | 108 | 90 | 0.25 | 70.01 ± 7.26 | 70.52 ± 7.11 | TaqMan | 8 |
| Wang [19] | 2013 | China | Asian | PB | 285 | 280 | 102 | 126 | 57 | 98 | 144 | 38 | 0.19 | NA | NA | HRM-PCR | 7 |
| Eeles [18] | 2008 | U.K. | Caucasian | PB | 1851 | 1887 | 35 | 406 | 1410 | 103 | 591 | 1193 | 0.01 | NA | NA | Illumina array | 7 |
| Parikh [22] | 2011 | U.S.A. | Caucasian | PB | 3150 | 2980 | 260 | 299 | 2591 | 261 | 288 | 2431 | <0.01 | NA | NA | GWAS | 8 |
| rs266882 | GG | GA | AA | GG | GA | AA | |||||||||||
| Cicek [16] | 2005 | U.S.A. | Caucasian | FB | 439 | 479 | 119 | 196 | 124 | 119 | 236 | 124 | 0.75 | NA | NA | PCR-RFLP | 6 |
| Lai [17] | 2007 | Australia | Caucasian | PB | 209 | 223 | 35 | 111 | 63 | 71 | 107 | 45 | 0.68 | 68 (50–91) | 50 (18–75) | PCR-RFLP | 8 |
| Penney [20] | 2011 | U.S.A. | Caucasian | PB | 966 | 1279 | 255 | 483 | 228 | 346 | 622 | 311 | 0.34 | 59 ± 8.3 | 59.3 ± 8.0 | Sequenom technology | 8 |
| rs1058205 | CC | CT | TT | CC | CT | TT | |||||||||||
| Penney [20] | 2011 | U.S.A. | Caucasian | PB | 896 | 1165 | 14 | 176 | 706 | 28 | 269 | 868 | 0.19 | 59 ± 8.3 | 59.3 ± 8.0 | Sequenom technology | 8 |
| Chen [21] | 2017 | China | Asian | HB | 268 | 298 | 4 | 55 | 209 | 7 | 89 | 202 | 0.44 | 58 (52–62) | 62 (52–67) | HRM-PCR | 7 |
| Eeles [18] | 2008 | U.K. | Caucasian | PB | 1850 | 1887 | 54 | 490 | 1306 | 136 | 674 | 1077 | 0.03 | NA | NA | Illumina array | 7 |
| Stegeman [23] | 2015 | Australia | Caucasian | PB | 22301 | 22320 | 446 | 5798 | 161057 | 670 | 6476 | 15177 | 0.53 | 64.8 ± 8.0 | 60.6 ± 10.7 | Illumina array | 8 |
| Parikh [22] | 2011 | U.S.A. | Caucasian | PB | 3515 | 3329 | 373 | 329 | 2813 | 410 | 298 | 2621 | <0.01 | NA | NA | GWAS | 8 |
Abbreviations: FB, family-based; GWAS, Genome-Wide Association Study; HB, hospital-based; HRM-PCR, high-resolution melting curve polymerase chain reaction; HWE, Hardy–Weinberg equilibrium of controls; NA, not available; NOS, Newcastle–Ottawa scale; PB, population-based; PCR-FLIP, polymerase chain reaction and restrictive fragment length polymorphism.